270 papers
This study reveals that Dyrk1a acts as a critical, gene-dosage-sensitive effector of the Lhx2 transcriptional hierarchy, where its proper expression is essential for bipolar cell survival, mosaic organization, and the functional stratification of retinal circuits.
This study reveals that oscillatory Hedgehog signaling, generated through a feedback loop involving the periodic expression of its receptor Patched, provides a temporal cue that synchronizes the pulsatile expression of the proneural gene *atonal* to ensure coordinated pattern formation along the differentiation front of the developing *Drosophila* eye.
This study constructs a temporally resolved single-cell chromatin accessibility atlas of zebrafish brain and retina development to map dynamic regulatory landscapes, link transcription factor activity to cell identity, and functionally validate conserved enhancer modules that orchestrate neural gene expression.
This study demonstrates in *Drosophila* that the co-repressor Groucho limits transcriptional progression through the promoter-proximal pausing checkpoint by modulating the activity of P-TEFb-dependent elongation regulators, thereby attenuating gene expression during development.
This study reveals that temporal Notch signaling and a mechanism termed "competitive de-repression," involving sequentially expressed Hes factors and Spdef-mediated regulation, orchestrate the specification of multiple mucociliary cell fates in Xenopus, thereby extending the traditional lateral inhibition paradigm to explain the generation of diverse cell types.
This study demonstrates that the temporal identity and Notch signaling status of Drosophila medulla neurons genetically determine their specific neuropil targeting depth and synapse location in the adult brain, thereby linking developmental patterning mechanisms directly to the functional architecture of visual circuits.
This study reveals that in *C. elegans* embryonic epidermis, the basolateral protein LGL-1 and the RhoGAP PAC-1 function redundantly to inhibit apical polarity determinants, preventing embryonic lethality caused by excessive apical expansion and epidermal rupture.
This study reveals that the apical junction protein AJM-1 establishes stochastic lateralization of *C. elegans* olfactory neurons by promoting SLO-1 expression and antagonizing mechanosensitive calcium signaling, thereby driving the specification of the AWCON subtype.
This study reveals that genome-wide, cell type-specific, and sex-specific transcriptional dysregulation in the islets of Langerhans underlies the increased risk of type 2 diabetes in individuals with Down syndrome.
This study reveals that theca cells actively secrete a hyaluronic acid-rich extracellular matrix which, through a mechanochemical feedback loop involving substrate stiffness and YAP signaling, regulates cell proliferation, motility, and overall follicle growth during mammalian ovarian development.
This study demonstrates that laminin and fibronectin in the extracellular matrix cooperate with chemical guidance cues to mechanically confine and guide the self-organization of endothelial cells during zebrafish intersegmental vessel formation, as revealed by combined in vivo imaging and hybrid mathematical modeling.
Male mice heterozygous for both Protamine-1 and Protamine-2 are infertile due to sperm DNA damage, impaired hypercondensation, and the retention of precursor proteins, despite having a normal mature protamine ratio, indicating that infertility in this context is better detected by assessing protamination levels and precursor retention rather than the final protamine ratio.
This study utilizes Goofy/123Cre lineage tracing to demonstrate that while Goofy broadly marks nasal chemosensory neurons and terminal nerve cells, it is absent in migrating GnRH-1 neurons, yet later reveals a distinct population of Goofy-expressing basal forebrain neurons with nasal origins, thereby clarifying the genetic heterogeneity and developmental trajectories of olfactory placode-derived cells.
By leveraging a single-cell transcriptome atlas of mouse pharyngeal endoderm, this study elucidates the gene regulatory networks and spatiotemporal mechanisms—specifically a partial epithelial-mesenchymal transition—that enable the merging of endoderm-derived thyroid and ultimobranchial progenitors into a dual endocrine gland, while revealing how mixed-type thyroid carcinoma recapitulates this developmental trajectory to drive invasive behavior.
This study optimizes the Stereo-cell high-density array platform to generate a comprehensive single-cell transcriptomic and morphological atlas of mouse oocyte development from growth to ovulation, revealing stage-specific transcriptional shifts and reconstructing granulosa cell relationships within their spatial tissue context.
This study demonstrates that planarians, despite lacking canonical RNA-dependent RNA polymerases, establish a heritable, long-term RNAi memory through a two-phase, post-transcriptional mechanism involving A-tailed antisense small RNAs that persists through regeneration and asexual reproduction.
This study reveals that in the developing *Drosophila* brain, Med12 and Med13 prevent tumorigenic dedifferentiation of intermediate neural progenitors and maintain neural stem cell self-renewal by differentially coordinating with or antagonizing specific subsets of core mediator complex subunits to regulate fate commitment and stemness.
This study combines a novel hybrid agent-based model with experimental validation to demonstrate that regenerative blastema formation is driven by local softening of the wounded epithelium and Wnt-mediated directed migration of mesenchymal cells.
This paper reveals that *Drosophila* germ-band extension employs a two-state remodeling strategy where the anterior tissue behaves as a fluidized state driven by internal myosin fluctuations, while the posterior tissue acts as a solid undergoing crystal-like ordering and plastic flow induced by external stresses, collectively solving the inhomogeneous reshaping challenge of embryogenesis.
This study establishes hormonally responsive bovine oviductal organoids that accurately mimic the native oviduct's phase-specific molecular signatures and functional secretions, thereby enhancing sperm capacitation and offering a sustainable platform for advancing assisted reproduction technologies.